28^th World Congress on Human Health Metabolism-Cancer, Obesity, and Diabetes November 25-26, 2020 Tokyo, Japan

Epigenetic alterations square measure functionally relevant modifications to the ordering that don't modification the ester sequence. samples of such modifications square measure changes in polymer methylation (hyper methylation and hypo methylation), simple protein modification and changes in body design (caused by inappropriate expression of proteins like HMGA2 or HMGA1 every of those alterations regulates organic phenomenon while not neutering the underlying polymer sequence. These changes might stay through cell divisions, last for multiple generations and may be thought-about to be equivalent to mutations.

Cancer is basically an unhealthy tissue growth regulation. so as for a traditional cell to remodel into a neoplastic cell, the genes that regulate cell growth and differentiation should be altered. The affected genes square measure divided into 2 broad classes. Oncogenes square measure genes that promote cell growth and copy. Tumor suppressor genes square measure genes that inhibit cellular division and survival. Malignant transformation will occur through the formation of novel oncogenes, the inappropriate over-expression of traditional oncogenes, or by the under-expression or disabling of tumor suppressor genes. Typically, changes in multiple genes square measure needed to remodel a traditional cell into a neoplastic cell.

The Mediterranean Diet is very important for the Diabetes Patient. It help in the improve of insulin Sensitivity. The women who can follow the proper Mediterranean diet can reduced their risk to the insulin resistance and the risk of developing type 2 diabetes. Mediterranean Diet has follow Daily eating, weekly eating, and Monthly eating.

Women who are affected by   gestational diabetes during pregnancy have a much higher risk of developing type2 diabetes during their lifetimes. Their children also have an increased risk for obesity and type 2 diabetes. This can be Reduce by taking some preventive measure. Type2 diabetes is a serious condition, which, if left untreated, can lead to sight loss, foot numbness and heart disease, as well as the risks associated with having a hypo.

Eating disorder is also called mental disorder by abnormal eating habits that negatively affect a person's physical or mental health. The number of Diseases are their like binge eating disorder, anorexia nervosa, bulimia nervosa, pica, rumination syndrome, avoidant/restrictive food intake. The preventive measures and Treatment for the eating disorder is this involves counselling, a proper diet, a normal amount of exercise and the reduction of efforts to eliminate food

Metabolism is a Chemical reaction that helps in the Converting of energy from our intake. Metabolism Consist of Catabolism and Anabolism Where Catabolism is process in which larger molecule break down into smaller molecule this reaction is called as Oxidation reaction. Anabolism is a process in which assembly of small molecule into larger molecule which is called as Reduction reaction. Metabolic Rate refers to the amount of chemical energy a person frees from their body per unit time.

There are different kind of diabetes are their mainly Type1 and Type2 Diabetes. These both major differences in effect of Health type 1Diabetes don’t produce insulin whereas type 2 Diabetes Don’t respond to insulin. Both type1 and type2 diabetes can lead to complications, such as cardiovascular disease, kidney disease, vision loss, neurological conditions, and damage to blood vessels and organs. Many people may be able to avoid type 2 by making healthful lifestyle choices

Maternal obesity is now considered as high risk factors seen in obstetric practice. The obesity women have more risk as compared to the healthy women in pregnancy. Obesity women during pregnancy Increased risk of miscarriage, gestational diabetes, preeclampsia, venous thromboembolism, caesarean section, anesthetic complications and wound infections. Babies of obese mothers may cause effect of stillbirth, congenital anomalies, prematurity, macrosomia and neonatal death

Diabetes is also a common chronic illness that occurs when your blood glucose level is too high. There are Different kind of diabetes like Type1 Diabetes, Type2 Diabetes and gestational diabetes. Diabetes results in abnormal metabolism of carbohydrates and elevated levels of glucose in the blood Because of body’s ability to produce or respond to the hormone insulin is impaired. Obesity refers to excessive fat accumulation in body that may cause the Health issues. Obesity Caused due to the excessive food intake, lack of physical activity, and genetic susceptibility. In the rare cases it also caused by the genes, endocrine disorders, medications, or mental disorder. The Obesity of the person depends on the Body mass index. Cancer is Consider of group of diseases that lead to the abnormal growth of cells with uncontrolled cell division. Cancer is a very Sevier Disease that may lead to the death of the person

Obesity also caused by the genetic factor and several genes that may contribute to weight gain and body fat distribution. Obesity people have multiple genes that predispose them to gain excess weight. One such sequence is that the fat mass and obesity-associated sequence (FTO), that is found in up to forty third of the population. In the Rare cases single-gene defects cause severe obesity beginning in early childhood and are associated with extremely high levels of hunger and experts reports that its due to Leptin Deficiency, POMC Deficiency, MC4R Deficiency.

Pediatric or childhood obesity is nutritional disorder that cause among children and adolescents worldwide. The main reasons for obesity among children and adults is consumption of fatty foods and a high sugar diet, as well as tobacco smoking, and no exercise qualify. Pediatric or childhood obesity caused by different factors that can be divided into genetic, behavioral and environmental factors. The prevention and treatment of pediatric obesity are new dietary, physical activity, behavioral, environmental, and pharmacological.

The Advanced Technology and Treatments for Diabetes are many and the availability of high level of equipment.  Current Research  new approach  on developing Implantable insulin pumps which introduces Insulin pump therapy, Artificial pancreas, invasive and non-invasive glucose sensors, disruption of fat metabolism, Insulin Pens, insulin delivery systems like inhaled, transdermal and implantable devices, Bariatric surgery and Conventional therapeutic approaches.  Diabetes also cured by the organ transplantation through organ transplantation, donor transplantation, tissue transplantation.

Diabetes is a major Disease that effect more population all over the world finding the correct and accurate medication is very important. Clinical trials are playing very important role in having the capacity to have new medications for diabetes and other varied conditions. A case study is a proper methodology and a strategy that investigates a phenomenon with its real-life context for giving the best result. Case studies and clinical trials are used to develop or access the quality of the medications being developed for various diseases

Diabetes is one of the major contributors to ill health and premature mortality worldwide. As the Diabetes disease states that Number of years having diabetes is directly proportional to the higher risk of complications. There are different type of Complications like Type1, Type2 Diseases, hypoglycemia, hyperglycemia, diabetic coma, and non-kenotic hyperosmolar coma. Chronic complications occur because of a combination of microangiopathy, macrovascular diseases. The Complications can be over by well controlled blood sugar level.

Scientists have suspected that the elevated cancer risk for diabetics arises from secretion dysregulation. "In folks with kind Diabetes, their internal secretion isn't effectively carrying also hexose into cells," Termini explain. "So the duct gland makes a lot of and a lot of internal secretion, and that they get what is referred to as hyperinsulinemia." additionally to dominant glucose levels, the internal secretion internal secretion will stimulate cell growth, presumably resulting in cancer. Also, most of the people with kind two polygenic disease are overweight, and their excess fat tissue produces higher levels of adipocytes than those at a healthy weight.

Obesity is defined as Body Mass Index of 30 that lead to the Higher Risk of the Cancer type diseases. Some of the cancer that is caused by the Obesity is the esophageal cancer, pancreatic cancer, colorectal cancer, breast cancer (among postmenopausal women), endometrial cancer, kidney cancer, thyroid cancer, liver cancer and gallbladder cancer. It also increases the Cancer mortality. The mechanism is the Obesity people affected by the adipose tissue environment and the endocrine alterations that may lead to promote tumor initiation and progression. It may also lead inflammatory environment that enhances the ability of tumor cells to metastasize